Anti-HBV surface antigen Antibody Fab

Cat

MOM-18147-F(P)

Product Overview

Recombinant Human Antibody Fab Fragment specifically binds to Hepatitis B surface antigen, expressed in E. coli

Target

Hepatitis B surface antigen

Type

Fab Fragment based on Human IgG1 - kappa

Species Reactivity

HBV

Expression Host

E. coli

Applications

Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.

Predicted N terminal

H chain: QVKLLES; L Chain: ELVMTQ

Purity

>95.0% as determined by analysis by SDS-PAGE.

Storage

At -20°C for one year.

Introduction

This is a human monoclonal antibody directed against the hepatitis B virus.

Antigen Description

HBV (HBV) infection induces a disease state which manifests itself in a variety of ways, characterized by the extent of liver damage, inflammation and viral persistence. HBV infection is also associated with a 100 fold increased risk of hepatocellular carcinoma and currently infects over 250 million people worldwide. HBV has a partially double stranded 3.2 kilobase DNA genome which contains four open reading frames. One of these encodes a 154 amino acid protein called the HBx protein. HBx has been shown to be a transcriptional transactivator of both viral and cellular promoters. Lacking a DNA binding domain and nuclear localization signal, HBx is believed to exert transcriptional activity through protein protein interaction.

Keywords

HBsAg; Hep B surface antigen; Hepatitis B Virus major surface antigen; Hepatitis B virus S antigen; Large envelope protein; Large surface protein; LHB; Major surface antigen

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