Recombinant Anti-Gp41 Single Domain Antibody

Cat

NAB-L121

Product Overview

Single Domain Antibody to HIV-1 Gp41.

Target

Gp41

Type

llama Single Domain Antibody

Immunogen

The details of the immunogen for this antibody are not available.

Species Reactivity

HIV-1

Expression Host

E.coli

Specificity

Tested positive against native HIV-1 antigen.

Storage

Store at -20°C. Avoid multiple freeze/thaw cycles.

Introduction

HIV-1 is the most common and pathogenic strain of the virus. Scientists divide HIV-1 into a Group M (major) and two or more minor groups.

Antigen Description

gp41/120 is the major HIV protein associated with the HIV envelope. It functions as the viral antireceptor or attachment protein. gp41 (or TM) traverses the envelope, whereas gp120 is present on the outer surface and is noncovalently attached to gp41. The precursor of gp120/41 (gp160) is synthesized in the endoplasmic reticulum and is transported via the golgi body to the cell surface. Upon activation of the envelope glycoprotein (gp120/41) by cellular receptors, gp41 undergoes conformational changes that mediate fusion of the viral and cellular membranes.

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