Recombinant Anti-Gp41 Single Domain Antibody (NAB-L121)
|Recombinant Anti-HIV-1 Gp41 Single Domain Antibody
- Product Overview
- Single Domain Antibody to HIV-1 Gp41.
- llama Single Domain Antibody
- The details of the immunogen for this antibody are not available.
- Specific Activity
- Tested positive against native HIV-1 antigen.
- Store at -20°C. Avoid multiple freeze/thaw cycles.
- HIV-1 is the most common and pathogenic strain of the virus. Scientists divide HIV-1 into a Group M (major) and two or more minor groups.
- Antigen Description
- gp41/120 is the major HIV protein associated with the HIV envelope. It functions as the viral antireceptor or attachment protein. gp41 (or TM) traverses the envelope, whereas gp120 is present on the outer surface and is noncovalently attached to gp41. The precursor of gp120/41 (gp160) is synthesized in the endoplasmic reticulum and is transported via the golgi body to the cell surface. Upon activation of the envelope glycoprotein (gp120/41) by cellular receptors, gp41 undergoes conformational changes that mediate fusion of the viral and cellular membranes.
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