Anti-APP Antibody Fab

Cat

MOM-18228-F(P)

Product Overview

Recombinant Humanized (from mouse) Antibody Fab Fragment is specific to Human Abeta, expressed in E. coli

Target

Abeta

Type

Fab Fragment based on Humanized (from mouse) IgG1 - kappa

Immunogen

The details of the immunogen for this antibody are not available.

Species Reactivity

Human

Expression Host

E. coli

Applications

Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.

Specificity

Tested positive against native antigen.

Predicted N terminal

H chain: EVQLVES; L Chain: DVVMTQS

Purity

Purity >95% by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Antigen Description

Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Defects in APP are the cause of Alzheimer disease type 1 (AD1) [MIM:104300]. AD1 is a familial early-onset form of Alzheimer disease.

Function

DNA binding; PTB domain binding; acetylcholine receptor binding; heparin binding; identical protein binding; peptidase activator activity; peptidase inhibitor activity; protein binding; receptor binding; serine-type endopeptidase inhibitor activity; transition metal ion binding;

Gene ID

351

Synonyms

APP; amyloid beta (A4) precursor protein; AD1, Alzheimer disease; amyloid beta A4 protein; peptidase nexin II; preA4; protease nexin-II; peptidase nexin-II; beta-amyloid peptide; alzheimer disease amyloid protein; cerebral vascular amyloid peptide; AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma;

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