Anti-APP Antibody (MOM-18225)
|Recombinant Anti-Human APP Antibody
- Product Overview
- Recombinant Humanized (from mouse) Antibody binds selectively to Human Abeta, expressed in Chinese Hamster Ovary cells(CHO)
- Humanized (from mouse) IgG1
- The details of the immunogen for this antibody are not available.
- Suitable for use in FuncS, IF, Neut, ELISA and most other immunological methods.
- Specific Activity
- Tested positive against native antigen.
- Protein Construction
- Immunoglobulin G1, anti-(human beta-amyloid) (human-mouse monoclonal heavy chain), disulfide with human-mouse monoclonal light chain, dimer
- >95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Antigen Description
- Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Defects in APP are the cause of Alzheimer disease type 1 (AD1) [MIM:104300]. AD1 is a familial early-onset form of Alzheimer disease.
- DNA binding; PTB domain binding; acetylcholine receptor binding; heparin binding; identical protein binding; peptidase activator activity; peptidase inhibitor activity; protein binding; receptor binding; serine-type endopeptidase inhibitor activity; transition metal ion binding;
- APP; amyloid beta (A4) precursor protein; AD1, Alzheimer disease; amyloid beta A4 protein; peptidase nexin II; preA4; protease nexin-II; peptidase nexin-II; beta-amyloid peptide; alzheimer disease amyloid protein; cerebral vascular amyloid peptide; AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma;
All listed customized services & products are for research use only, not intended for pharmaceutical, diagnostic, therapeutic or any in vivo human use.