Anti-C5 Antibody

Cat

MOM-18008

Product Overview

Recombinant Humanized (from mouse) Antibody is bind to Human C5, expressed in Chinese Hamster Ovary cells(CHO)

Target

C5

Type

Humanized (from mouse) IgG2 / G4 - kappa

Immunogen

Human C5 protein emulsified with complete Fraud's adjuvant

Species Reactivity

Human

Expression Host

CHO

Applications

Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, WB and most other immunological methods.

Specificity

Tested positive against native antigen.

Protein Construction

Immunoglobulin, anti-(human complement C5 a-chain) (human-mouse monoclonal 5G1.1 heavy chain), disulfide with human-mouse monoclonal 5G1.1 light chain, dimer

Predicted N terminal

H chain: MADLQMT; L Chain: MGIQGGS

Purity

>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.

Storage

Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.

Antigen Description

C5 is synthesised in the liver as a single polypeptide chain. Before secretion the molecule is glycosylated and secreted into plasma as a 190 kDa glycoprotein consisting of a disulphide linked alpha-chain (111 kDa) and beta-chain (75 kDa). C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha chain).

Function

C5a anaphylatoxin chemotactic receptor binding; chemokine activity; endopeptidase inhibitor activity; receptor binding;

Gene ID

727

Synonyms

C5; complement component 5; complement C5; CPAMD4; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; FLJ17816; FLJ17822; MGC142298;

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