Anti-CD40LG Antibody Fab

Cat

MOM-18027-F(E)

Product Overview

Recombinant Humanized (from mouse) Antibody Fab Fragment binds selectively to Human CD40L, expressed in Chinese Hamster Ovary cells(CHO cells)

Target

CD40L

Type

Fab Fragment based on Humanized (from mouse) IgG1 - kappa

Immunogen

Animals were immunized with D1.1 cells.

Species Reactivity

Human

Expression Host

CHO

Applications

Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.

Specificity

Tested positive against native antigen.

Purity

>95%, by SDS-PAGE with silver staining, under reducing conditions.

Storage

Store at -20°C. Avoid multiple freeze/thaw cycles.

Antigen Description

Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.

Function

CD40 receptor binding; cytokine activity; tumor necrosis factor receptor binding;

Gene ID

959

Keywords

0

Synonyms

CD40LG; CD40 ligand; HIGM1, IMD3, TNFSF5, tumor necrosis factor (ligand) superfamily, member 5 (hyper IgM syndrome); CD40 antigen ligand; CD40L; CD154; gp39; hCD40L; hyper IgM syndrome; T B cell activating molecule; TNF related activation protein; TRAP; tumor necrosis factor (ligand) superfamily member 5; CD40-L; T-cell antigen Gp39; T-B cell-activating molecule; TNF-related activation protein; IGM; IMD3; HIGM1; T-BAM; TNFSF5;

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