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Recombinant Chimeric (mouse/human) Antibody scFv Fragment specifically binds to Human GD3 ganglioside, expressed in E. coli
scFv Fragment from Chimeric (mouse/human) IgG1 - kappa
The details of the immunogen for this antibody are not available.
Suitable for use in ELISA, WB, Neut and most other immunological methods.
Tested positive against native antigen.
>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
This is a chimeric monoclonal antibody being developed for the treatment of malignant melanoma.
Almost all melanomas, astrocytomas, a proportion of sarcomas, a small number of carcinomas, some nevi, as well as normal melanocytes express GD3 antigen. It is one of the most important markers for malignant melanoma. Antibodies to the GD3 ganglioside can induce partial remission of tumor growth in animals as well as in Humans via enhancement of cytotoxic and proliferative response of lymphocytes.