Anti-GFAP Single Domain Antibody

Cat

NAB-LXY0004

Target

GFAP

Type

llama VHH

Immunogen

The details of the immunogen for this antibody are not available.

Species Reactivity

Human

Expression Host

E.coli

Specificity

Tested positive against native human antigen.

Storage

4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

Antigen Description

Glial fibrillary acidic protein (GFAP) is a protein that is encoded by the GFAP gene in humans.

Glial fibrillary acidic protein is an intermediate filament (IF) protein that is expressed by numerous cell types of the central nervous system (CNS) including astrocytes, and ependymal cells. GFAP has also been found to be expressed in glomeruli and peritubular fibroblasts taken from rat kidneys Leydig cells of the testis in both hamsters and humans, human keratinocytes, human osteocytes and chondrocytes and stellate cells of the pancreas and liver in rats. First described in 1971, GFAP is a type III IF protein that maps, in humans, to 17q21. It is closely related to its non-epithelial family members, vimentin, desmin, and peripherin, which are all involved in the structure and function of the cell's cytoskeleton. GFAP is thought to help to maintain astrocyte mechanical strength, as well as the shape of cells but its exact function remains poorly understood, despite the number of studies using it as a cell marker. Glial fibrillary acidic protein (GFAP) was named and first isolated and characterized by Lawrence F. Eng in 1969.

Function

integrin binding; kinase binding; structural constituent of cytoskeleton.

Gene ID

2670

Synonyms

GFAP; glial fibrillary acidic protein; FLJ45472; intermediate filament protein; FLJ42474

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