Anti-IL2RA Antibody scFv

Cat

MOM-18023-S(P)

Product Overview

Recombinant Humanized (from mouse) Antibody scFv Fragment is against Human CD25, expressed in E. coli

Target

CD25

Type

scFv Fragment from Humanized (from mouse) IgG1 - kappa

Immunogen

The details of the immunogen for this antibody are not available.

Species Reactivity

Human

Expression Host

E. coli

Applications

Suitable for use in ELISA, WB, Neut and most other immunological methods.

Specificity

Tested positive against native antigen.

Purity

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Storage

Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.

Antigen Description

CD25 is the alpha chain of the IL-2 receptor. It is a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes that associates with CD122 to form a heterodimer that can act as a high-affinity receptor for IL-2. Though CD25 has been used as a marker to identify CD4+FoxP3+ regulatory T cells in mice, it has been found that a large proportion of resting memory T cells constitutively express CD25 in humans. CD25 is expressed in most B-cell neoplasms, some acute nonlymphocytic leukemias, neuroblastomas, and tumor infiltrating lymphocytes. Its soluble form, called sIL-2R may be elevated in these diseases and is occasionally used to track disease progression.

Function

drug binding; interleukin-2 binding; interleukin-2 receptor activity; receptor activity;

Gene ID

3559

Synonyms

IL2RA; interleukin 2 receptor, alpha; IL2R; interleukin-2 receptor subunit alpha; CD25; p55; IL2-RA; IL-2-RA; TAC antigen; IL-2R subunit alpha; IL-2 receptor subunit alpha; TCGFR; IDDM10;

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