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Anti-ITGA2B Antibody Fab (MOM-18015-F(E))

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human ITGA2B Antibody Fab Fragment MOM-18015-F(E) 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Chimeric (mouse/human) Antibody Fab Fragment is specific to Human CD41, expressed in Chinese Hamster Ovary cells(CHO)
  • Target
  • CD41
  • Type
  • Fab Fragment based on Chimeric (mouse/human) Fab - G1 - kappa
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
  • Specificity
  • Tested positive against native antigen.
  • Protein Construction
  • Immunoglobulin G1, anti-(human integrin alpha Iib beta 3) Fab fragment (human-mousemonoclonal c7E3 clone gamma 1-chain), disulfide with human-mouse monoclonal c7E3 clone kappa-chain
  • Purity
  • >95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
  • Storage
  • Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

BACKGROUND

  • Antigen Description
  • Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
  • Function
  • extracellular matrix binding; identical protein binding; protein binding; receptor activity;
  • Synonyms
  • ITGA2B; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); GP2B, integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B); integrin alpha-IIb; CD41; CD41B; GPalpha IIb; platelet-specific antigen BAK; platelet membrane glycoprotein IIb; platelet fibrinogen receptor, alpha subunit; GT; GTA; GP2B; HPA3; GPIIb; BDPLT2;

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