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Recombinant Human Antibody is bind to Human CD51, expressed in Chinese Hamster Ovary cells(CHO)
Human IgG1 - kappa
Suitable for use in FuncS, IF, Neut, ELISA and most other immunological methods.
Tested positive against native antigen.
Immunoglobulin G1, anti-(human integrin alpha-V (vitronectin receptor subunit alpha or CD51); human monoclonal CNTO 95 γ1 heavy chain (222-215")-disulfide with human monoclonal CNTO 95 kappa light chain dimer (228-228"":231-231"")-bisdisulfide
Predicted N terminal
H Chain: QVQLVES; L Chain: EIVLTQS
>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi"s sarcoma lesions.
contributes_to insulin-like growth factor I binding; contributes_to opsonin binding; protein binding; protein kinase C alpha binding; contributes_to protein kinase C binding; receptor activity; transforming growth factor beta binding;