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Recombinant Humanized (from mouse) Antibody Fab Fragment is against Human MUC1, expressed in Chinese Hamster Ovary cells(CHO)
Fab Fragment based on Humanized (from mouse) Fab - G1 - kappa
The details of the immunogen for this antibody are not available.
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Tested positive against native antigen.
Predicted N terminal
H chain: QVQLQQS; L Chain: DIQLTQS
>95%, by SDS-PAGE with silver staining, under reducing conditions.
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
RNA polymerase II core promoter proximal region sequence-specific DNA binding; p53 binding; protein binding; transcription cofactor activity;