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Recombinant Humanized (from mouse) Antibody is against Human MUC1, expressed in Chinese Hamster Ovary cells(CHO)
Humanized (from mouse) IgG1 - kappa
Synthetic peptide, corresponding to residues from the C-terminus of Human MUC1.
Suitable for use in Neut, ELISA and most other immunological methods.
Tested positive against native antigen.
Inmunoglobulina G1-kappa, anti-[Homo sapiens glicano sialilo de MUC1, asociado al tumor (CA242, antígeno del cancer 242)] anticuerpo monoclonal humanizado conjugado con el maitansinoide DM4
Predicted N terminal
H chain: QVQLVQS; L Chain: DIVMTQS
Purity >95% by SDS-PAGE.
Store at -20°C. Avoid multiple freeze/thaw cycles.
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
RNA polymerase II core promoter proximal region sequence-specific DNA binding; p53 binding; protein binding; transcription cofactor activity;