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Recombinant Human Antibody is specific to Human RHD, expressed in Chinese Hamster Ovary cells(CHO)
Human IgG1 - kappa
Tissue / cell preparation (Human) - erythrocytes.
Suitable for use in WB, ELISA, FC, IP, FuncS, IF, Neut and most other immunological methods.
Immunoglobulin G1-kappa, anti-[Homo sapiens RHD (Rhesus bloodgroup D antigen, RhD, CD240D)], Homo sapiens monoclonalantibody;gamma1 heavy chain (1-456) [Homo sapiens VH (IGHV3-30*01(86.70%) -(IGHD)-IGHJ3*02) [8.8.19] (1-126) -IGHG1*01 (127-456)], (229-214
Predicted N terminal
H chain: DVQLVES; L Chain: ATRMTQS
>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Store at -20°C. Avoid multiple freeze/thaw cycles.
The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript variants encoding different isoforms have been found for this gene.