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Recombinant Human Antibody Fab Fragment is directed against Human RTN-4, expressed in Chinese Hamster Ovary cells(CHO)
Fab Fragment based on Human IgG4 - kappa
The details of the immunogen for this antibody are not available.
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Predicted N terminal
H chain: EVQLVES; L Chain: EIVLTQS
>95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Store at -20°C. Avoid multiple freeze/thaw cycles.
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.