Anti-SOST Antibody Fab

Cat

MOM-18116-F(E)

Product Overview

Recombinant Humanized (from mouse) Antibody Fab Fragment specifically binds to Human SOST, expressed in Chinese Hamster Ovary cells(CHO)

Target

SOST

Type

Fab Fragment based on Humanized (from mouse) IgG2 - kappa

Immunogen

The details of the immunogen for this antibody are not available.

Species Reactivity

Human

Expression Host

CHO

Applications

Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.

Specificity

Tested positive against native antigen.

Predicted N terminal

H chain: EVQLVQS; L Chain: DIQMTQS

Purity

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Storage

4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

Antigen Description

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antaggedonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Function

heparin binding; protein binding; transcription factor binding;

Gene ID

50964

Synonyms

SOST; sclerostin; sclerosteosis; VBCH;

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