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Recombinant Humanized (from mouse) Antibody is specific to Human SOST, expressed in Chinese Hamster Ovary cells(CHO)
Humanized (from mouse) IgG4 - kappa
The details of the immunogen for this antibody are not available.
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, WB and most other immunological methods.
Tested positive against native antigen.
Immunoglobulin G4, anti-(human sclerostin) (human-Mus musculus monoclonal heavy chain), disulfide with human-Mus musculus monoclonal Kappa-chain, dimer
Predicted N terminal
H chain: QVQLVQS; L Chain: DIQMTQS
>95.0% as determined by analysis by RP-HPLC.
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antaggedonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
heparin binding; protein binding; transcription factor binding;