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Anti-SOST Antibody (MOM-18116)

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human SOST Antibody MOM-18116 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Humanized (from mouse) Antibody binds selectively to Human SOST, expressed in Chinese Hamster Ovary cells(CHO)
  • Target
  • SOST
  • Type
  • Humanized (from mouse) IgG2 - kappa
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
  • Specificity
  • Tested positive against native antigen.
  • Protein Construction
  • Immunoglobulin G2-kappa, anti-[Homo sapiens SOST (sclerostin)], humanized monoclonal antibody
  • Predicted N terminal
  • H chain: EVQLVQS; L Chain: DIQMTQS
  • Purity
  • >95%, by SDS-PAGE with silver staining, under reducing conditions.
  • Storage
  • Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.

BACKGROUND

  • Antigen Description
  • Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antaggedonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
  • Function
  • heparin binding; protein binding; transcription factor binding;
  • Synonyms
  • SOST; sclerostin; sclerosteosis; VBCH;

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