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Recombinant Human Antibody is bind to Human TNF alpha, expressed in Chinese Hamster Ovary cells(CHO)
Human IgG1 - kappa
Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, IHC and most other immunological methods.
Tested positive against native antigen.
Immunoglobulin G1, anti (human tumor necrosis factor) (human monoclonal CNTO148 heavy chain), disulfide with human monoclonal CNTO148 light chain), dimer
Predicted N terminal
H Chain: QVQLVES; L Chain: EIVLTQS
>95.0% as determined by analysis by RP-HPLC.
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
cytokine activity; identical protein binding; protease binding; protein binding; transcription regulatory region DNA binding; tumor necrosis factor receptor binding;