Anti-TPBG Antibody Fab

Cat

MOM-18118-F(P)

Product Overview

Recombinant Mouse Antibody Fab Fragment is bind to Human 5T4, expressed in E. coli

Target

5T4

Type

Fab Fragment based on Mouse Fab - G1 - kappa

Immunogen

The details of the immunogen for this antibody are not available.

Species Reactivity

Human

Expression Host

E. coli

Applications

Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.

Specificity

Tested positive against native antigen.

Protein Construction

Immunoglobulin fragment, anti-[trophoblast glycoprotein (TPBG,5T4)] monoclonal 5T4 gamma1 heavy chain fragment fusion protein[Mus musculus VH (5T4V14: H41>P, S44>G, I69>T, V113>G)-IGHG1_CH1)] - [Glycyl-Glycyl-Prolyl] - superantigen SEA/E-120(synthetic), n

Purity

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Storage

Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.

Antigen Description

5T4 is a 72 kDa transmembrane glycoprotein that exhibits restricted expression in human and mouse adult tissues, is upregulated on many carcinomas and tumour expression correlates with poorer clinical outcome in ovarian, gastric and colorectal cancers. mES cells lack cell surface expression of the 5T4 antigen, and both protein and mRNA are rapidly upregulated following induction of differentiation. This proteins expression correlates with downregulation of OCT-4 and Tra-1–60.

Gene ID

7162

Synonyms

TPBG; trophoblast glycoprotein; 5T4; 5T4 AG; 5T4 oncofetal antigen; 5T4 oncotrophoblast glycoprotein; 5T4 oncofetal trophoblast glycoprotein; M6P1; 5T4AG;

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