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Recombinant Mouse Antibody Fab Fragment binds selectively to Human CD46, expressed in E. coli
Tissue / cell preparation (Human). (T cell line HPB-ALL).
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Tested positive against native antigen.
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.