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Recombinant Mouse Antibody Fab Fragment specifically binds to Human CD59, expressed in Chinese Hamster Ovary cells(CHO)
Thymocytes and T lymphocytes.
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Tested positive against native antigen.
>95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.