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Recombinant Mouse Antibody scFv Fragment is directed against Human CD59, expressed in E. coli
Thymocytes and T lymphocytes.
Suitable for use in ELISA, WB, Neut and most other immunological methods.
Tested positive against native antigen.
Purity >95% by SDS-PAGE.
At -20°C for one year.
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.