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Recombinant Mouse Antibody binds selectively to Human CD59, expressed in Chinese Hamster Ovary cells(CHO)
Thymocytes and T lymphocytes.
Suitable for use in FC, IP, ELISA, Neut and most other immunological methods.
Tested positive against native antigen.
>95.0% as determined by analysis by RP-HPLC.
Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.