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Recombinant Mouse Antibody is against Human CRCP, expressed in Chinese Hamster Ovary cells(CHO)
The details of the immunogen for this antibody are not available.
Suitable for use in Neut, FuncS, IF and most other immunological methods.
Tested positive against native antigen.
Purity >95% by SDS-PAGE.
Store at -20°C. Avoid multiple freeze/thaw cycles.
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway.