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Recombinant Mouse Antibody is specific to Human EPOR, expressed in Chinese Hamster Ovary cells(CHO)
Human recombinant EPO Receptor (extracellular domain)
Suitable for use in FC, IP, ELISA, Neut and most other immunological methods.
Tested positive against native antigen.
>95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.
erythropoietin receptor activity; identical protein binding; protein binding; receptor activity;