Anti-itgb7 Antibody Fab

Cat

MOM-18415-F(E)

Product Overview

Recombinant Mouse Antibody Fab Fragment specifically binds to Human ITGB7, expressed in Chinese Hamster Ovary cells(CHO)

Target

ITGB7

Type

Fab

Immunogen

TK1 murine t-cell lymphoma

Species Reactivity

Human

Expression Host

CHO

Applications

Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.

Specificity

Tested positive against native antigen.

Purity

>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.

Storage

At -20°C for one year.

Antigen Description

Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

Function

binding; metal ion binding; receptor activity;

Gene ID

3695

Synonyms

ITGB7; integrin, beta 7; integrin beta-7; integrin beta 7 subunit; gut homing receptor beta subunit

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