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Recombinant Mouse Antibody is specific to Human MCM7, expressed in Chinese Hamster Ovary cells(CHO)
Recombinant full length Human MCM7 protein
Suitable for use in Neut, ICC and most other immunological methods.
Tested positive against native antigen.
>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for "once per cell cycle" DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.
ATP binding; contributes_to ATP-dependent DNA helicase activity; contributes_to DNA binding; hydrolase activity; nucleotide binding; protein binding; single-stranded DNA binding;