Anti-notch1 Antibody Fab

Cat

MOM-18596-F(E)

Product Overview

Recombinant Mouse Antibody Fab Fragment is bind to Human NOTCH1, expressed in Chinese Hamster Ovary cells(CHO)

Target

NOTCH1

Type

Fab

Immunogen

The details of the immunogen for this antibody are not available.

Species Reactivity

Human

Expression Host

CHO

Applications

Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.

Specificity

Tested positive against native antigen.

Purity

Purity >95% by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Antigen Description

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function.

Function

calcium ion binding; chromatin DNA binding; core promoter binding; protein binding; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;

Gene ID

4851

Synonyms

NOTCH1; notch 1; Notch (Drosophila) homolog 1 (translocation associated) , Notch homolog 1, translocation associated (Drosophila) , TAN1; neurogenic locus notch homolog protein 1; Notch homolog 1, translocation-associated; translocation-associated notch protein TAN-1; hN1; TAN1;

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