Anti-notch1 Antibody scFv (MOM-18596-S(P))
|Recombinant Anti-Human notch1 Antibody scFv Fragment
- Product Overview
- Recombinant Mouse Antibody scFv Fragment specifically binds to Human NOTCH1, expressed in E. coli
- The details of the immunogen for this antibody are not available.
- Suitable for use in ELISA, WB, Neut and most other immunological methods.
- Specific Activity
- Tested positive against native antigen.
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
- Antigen Description
- Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function.
- calcium ion binding; chromatin DNA binding; core promoter binding; protein binding; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
- NOTCH1; notch 1; Notch (Drosophila) homolog 1 (translocation associated) , Notch homolog 1, translocation associated (Drosophila) , TAN1; neurogenic locus notch homolog protein 1; Notch homolog 1, translocation-associated; translocation-associated notch protein TAN-1; hN1; TAN1;
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