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Anti-notch3 Antibody Fab (MOM-18450-F(P))

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human notch3 Antibody Fab Fragment MOM-18450-F(P) 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Mouse Antibody Fab Fragment binds selectively to Human NOTCH3, expressed in E. coli
  • Target
  • NOTCH3
  • Type
  • Fab
  • Species Reactivity
  • Human
  • Expression Host
  • E. coli
  • Applications
  • Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
  • Specificity
  • Tested positive against native antigen.
  • Purity
  • >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
  • Storage
  • Store at -20°C. Avoid multiple freeze/thaw cycles.

BACKGROUND

  • Antigen Description
  • Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.
  • Function
  • calcium ion binding; protein binding; receptor activity;
  • Synonyms
  • NOTCH3; notch 3; CADASIL, Notch (Drosophila) homolog 3 , Notch homolog 3 (Drosophila); neurogenic locus notch homolog protein 3; CASIL; Notch homolog 3; CADASIL

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