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Recombinant Mouse Antibody is specific to Human P2RX7, expressed in Chinese Hamster Ovary cells(CHO)
Suitable for use in Neut, FuncS, ELISA, FC and most other immunological methods.
Tested positive against native antigen.
>95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
The product P2RX7 belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression.
ATP binding; ATP binding; extracellular ATP-gated cation channel activity; ion channel activity; lipopolysaccharide binding; protein homodimerization activity; purinergic nucleotide receptor activity; receptor activity; receptor binding;