Anti-rgma Antibody Fab

Cat

MOM-18485-F(E)

Product Overview

Recombinant Mouse Antibody Fab Fragment is directed against Human RGMA, expressed in Chinese Hamster Ovary cells(CHO)

Target

RGMA

Type

Fab

Species Reactivity

Human

Expression Host

CHO

Applications

Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.

Specificity

Tested positive against native antigen.

Purity

>95.0% as determined by analysis by RP-HPLC.

Storage

Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.

Antigen Description

The Repulsive Guidance Molecule (RGM) family of proteins function as BMP co-receptors. It is hypothesized that RGM family members increase the sensitivity of cells in which they are expressed to BMP stimulation, thereby allowing these cells to respond earlier or more robustly to a low level of BMP ligand. RGM family members are an important addition to the complex array of regulatory molecules which help to generate specificity and tightly coordinate cellular responses to BMP ligands. RGM-A and RGM-B (DRAGON) are expressed in a complementary manner in the central nervous system; whilst RGM-A mediates repulsive axonal guidance and neural tube closure, DRAGON contributes to neuronal cell adhesion through homophilic interactions. RGMa also binds to the receptor neogenin and functions as a cell survival factor.

Gene ID

56963

Synonyms

RGMA; RGM domain family, member A; repulsive guidance molecule A; RGM

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