Anti-timp1 Antibody scFv

Cat

MOM-18506-S(P)

Product Overview

Recombinant Mouse Antibody scFv Fragment specifically binds to Human TIMP1, expressed in E. coli

Target

TIMP1

Type

scFv

Immunogen

BALB/C mice were injected with recombinant human TIMP-1.

Species Reactivity

Human

Expression Host

E. coli

Applications

Suitable for use in ELISA, WB, Neut and most other immunological methods.

Specificity

Tested positive against native antigen.

Purity

>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Antigen Description

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.

Function

enzyme inhibitor activity; metal ion binding; metalloendopeptidase inhibitor activity; metalloendopeptidase inhibitor activity; protein binding;

Gene ID

7076

Synonyms

TIMP1; TIMP metallopeptidase inhibitor 1; CLGI, TIMP, tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor); metalloproteinase inhibitor 1; EPO; TIMP-1; collagenase inhibitor; erythroid potentiating activity; erythroid-potentiating activity; fibroblast collagenase inhibitor; tissue inhibitor of metalloproteinases 1; EPA; HCI; CLGI; TIMP; FLJ90373

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