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Recombinant Mouse Antibody is against Human TIMP1, expressed in Chinese Hamster Ovary cells(CHO)
BALB/C mice were injected with recombinant human TIMP-1.
Suitable for use in Neut, FuncS, IF and most other immunological methods.
Tested positive against native antigen.
>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
At -20°C for one year.
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
enzyme inhibitor activity; metal ion binding; metalloendopeptidase inhibitor activity; metalloendopeptidase inhibitor activity; protein binding;