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Recombinant Mouse Antibody Fab Fragment is directed against Human TNFRSF10A, expressed in Chinese Hamster Ovary cells(CHO)
Fusion protein (Human). Fusion protein containing the extracellular part of DR4 and the constant part of the heavy chain of the human IgG1.
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Tested positive against native antigen.
Purity >95% by SDS-PAGE.
Store at -20°C. Avoid multiple freeze/thaw cycles.
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
TRAIL binding; death receptor activity; protein binding; receptor activity; transcription factor binding;