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Recombinant Mouse Antibody scFv Fragment is bind to Human TNFRSF1A, expressed in E. coli
Suitable for use in ELISA, WB, Neut and most other immunological methods.
Tested positive against native antigen.
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.