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Recombinant Mouse Antibody is against Human TSHR, expressed in Chinese Hamster Ovary cells(CHO)
Fusion protein, corresponding to amino acids 402-415 of Human TSH receptor.
Suitable for use in Neut, ELISA, IHC and most other immunological methods.
Tested positive against native antigen.
>95.0% as determined by analysis by RP-HPLC.
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
The TSH receptor, a G protein coupled seven transmembrane receptor, is present on the basal surface of thyroid follicular cells. It is involved in regulating thyrocyte cell growth and function by mediating thyroid stimulating hormone (TSH) action. The TSH receptor is also the target autoantigen in autoimmune thyroid diseases. Autoantibodies to the TSH receptor that stimulate cAMP production in thyrocyte cells, called thyroid stimulating antibodies, are responsible for the hyperthyroidism of Graves" Disease. Another class of autoantibodies that block the binding of TSH to the TSH receptor, thyroid blocking antibodies, may mediate the hypothyroidism associated with Hashimoto's thyroiditis, primary myxoedema, and neonatal hypothyroidism. Studies indicate that these autoantibodies interact primarily with the extracellular region of the TSH receptor. TSH receptor expression has been reported in adipose, adrenal, brain, eye, heart, kidney, skin, thymus, and thyroid. ESTs have been isolated from brain, placenta, and thyroid libraries.
protein binding; receptor activity; signal transducer activity; thyroid-stimulating hormone receptor activity; thyroid-stimulating hormone receptor activity;