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Recombinant Mouse Antibody Fab Fragment binds selectively to Human UNC5B, expressed in E. coli
The details of the immunogen for this antibody are not available.
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Tested positive against native antigen.
>95.0% as determined by analysis by RP-HPLC.
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
netrin receptor activity; protein binding; receptor activity;
UNC5B; unc-5 homolog B (C. elegans); unc5 (C.elegans homolog) b; netrin receptor UNC5B; p53RDL1; UNC5H2; unc-5 homolog 2; protein unc-5 homolog 2; protein unc-5 homolog B; transmembrane receptor Unc5H2; p53-regulated receptor for death and life protein 1;