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Recombinant Human Angiostatin produced in Pichia has a molecular mass of 30498.6Da.
0.55×105 Units/mg by Anti-migration Assay.The activity is assayed on anti-proliferation and anti-migration of endothelial cells in vitro and anti-angiogenesis in vivo.
less than 10EU/mg as determined by LAL method
≥95% as determined by SDS-PAGE and HPLC
At 4℃ for 6 months and -80℃ for 2 years
PDB rendering based on 1b2i.
Angiostatin is a ~30 kDa fragment of plasminogen that has been shown to act as a potent inhibitor of angiogenesis and tumor growth in vitro and in vivo. Recombinant angiostatin is expressed in E. coli.
apolipoprotein binding; calcium ion binding; peptidase activity.