Recombinant Anti-CDH11 Mab

Cat

HOM-19240

Product Overview

Recombinant humanized antibody expressed in CHO binding to human CDH11.

Target

CDH11

Type

Human IgG

Species Reactivity

Human

Expression Host

CHO

Applications

ELISA, WB, IHC, FCM, IP, IF. Optimal dilutions/concentrations should be determined by the end user.

Clone

Monoclonal

Molecular Weight

145.41 kDa

Purity

>95.0% as determined by analysis by RP-HPLC & analysis by SDS-PAGE.

Storage

Store it under sterile conditions at -20 °C upon receiving. Recommend to pack the antibody into smaller quantities for optimal storage.

Stability

Samples are stable for up to twelve months from date of receipt at - °C and are stable for six months at 4 °C.

Ship

2-8°C, BLUE ICE

Antigen Description

Cadherin-11 is a protein that in humans is encoded by the CDH11 gene. This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. The mammalian CDH-11 homologues are termed calsyntenin.

Function

calcium ion binding;

Gene ID

1009

Synonyms

CDH11; cadherin 11, type 2, OB-cadherin (osteoblast); cadherin-11; CAD11; OB; OB Cadherin; CDHOB; OSF-4;

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