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Recombinant Anti-uPA Mab (HOM-19492)

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Human Anti-Human uPA Monoclonal Antibody HOM-19492 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant humanized antibody expressed in CHO binding to human uPA.
  • Target
  • Plau
  • Type
  • Human IgG
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • ELISA, WB, IHC, FCM, IP, IF. Optimal dilutions/concentrations should be determined by the end user.
  • Clone
  • Monoclonal
  • Molecular Weight
  • 145.41 kDa
  • Purity
  • >95.0% as determined by analysis by RP-HPLC & analysis by SDS-PAGE.
  • Storage
  • Store it under sterile conditions at -20 °C upon receiving. Recommend to pack the antibody into smaller quantities for optimal storage.
  • Stability
  • Samples are stable for up to twelve months from date of receipt at - 20°C and are stable for six months at 4 °C.
  • Ship
  • 2-8°C, BLUE ICE

BACKGROUND

  • Antigen Description
  • This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell
    migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's
    disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by
    specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to
    form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the
    catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular
    weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into
    a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the
    uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this
    gene. (provided by RefSeq, Feb 2009)
  • Function
  • peptidase activity; protein binding; serine-type endopeptidase activity;
  • Synonyms
  • PLAU; plasminogen activator, urokinase; urokinase-type plasminogen activator; UPA; URK; U-plasminogen activator; plasminogen activator, urinary; ATF; QPD; u-PA; BDPLT5;

Related Products

All listed customized services & products are for research use only, not intended for pharmaceutical, diagnostic, therapeutic or any in vivo human use.

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