Recombinant Anti-uPA Mab (HOM-19492)
|Recombinant Human Anti-Human uPA Monoclonal Antibody
- Product Overview
- Recombinant humanized antibody expressed in CHO binding to human uPA.
- ELISA, WB, IHC, FCM, IP, IF. Optimal dilutions/concentrations should be determined by the end user.
- Molecular Weight
- 145.41 kDa
- >95.0% as determined by analysis by RP-HPLC & analysis by SDS-PAGE.
- Store it under sterile conditions at -20 °C upon receiving. Recommend to pack the antibody into smaller quantities for optimal storage.
- Samples are stable for up to twelve months from date of receipt at - 20°C and are stable for six months at 4 °C.
- Antigen Description
- This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell
migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's
disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by
specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to
form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the
catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular
weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into
a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the
uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Feb 2009)
- peptidase activity; protein binding; serine-type endopeptidase activity;
- PLAU; plasminogen activator, urokinase; urokinase-type plasminogen activator; UPA; URK; U-plasminogen activator; plasminogen activator, urinary; ATF; QPD; u-PA; BDPLT5;
All listed customized services & products are for research use only, not intended for pharmaceutical, diagnostic, therapeutic or any in vivo human use.