Recombinant Human Bone Morphogenetic Protein -2

Cat

CRP0801

Product Overview

Recombinant Human Bone Morphogenetic protein-2 produced in E. coli is a homodimeric, non-glycosylated, Polypeptide chain containing 115 amino acids and having a molecular mass of 26.018 kDa.

Specificity

BMP-2 is fully biologically active when compared to standard. The ED50 as determined by the cytolysis of MC3T3-E1 cells is less than 50 ng/ml, corresponding to a specific activity of 2.0 x 104 IU/mg.

Endotoxin

Less than 0.1ng/ug (1IEU/ug) of Bone Morphogenetic protein-2 .

Purity

>95% by SDS-PAGE and SEC-HPLC.

Storage

Lyophilized BMP2 although stable at room temperature for 3 weeks, should be stored desiccated below -18^oC. Upon reconstitution BMP2 should be stored at 4^oC between 2-7 days and for future use below -18^oC. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Aliquot to avoid repeated freeze-thaw cycles.

Reconstitution

It is recommended to reconstitute the lyophilized rHuBMP2 in sterile 20mM Acetic acid not less than 100ug/ml, which can then be further diluted to other aqueous solutions.

PDB rendering based on 3bmp.

Antigen Description

Bone morphogenetic protein 2 (BMP-2) is a protein that belongs to the TGF-β superfamily of proteins. It, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. It is involved in the Hedgehog pathway, TGF-beta signaling pathway, and the Cytokine-cytokine receptor interaction. It is involved also in cardiac cell differentiation and epithelial to mesenchymal transition.

Function

Cytokine activity, Growth factor activity, Specific transcriptional repressor activity

Gene ID

650

Synonyms

BMP2A; BMP-2; BMP-2A; Bone morphogenetic protein 2 precursor

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