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Recombinant Human C-Terminal Fragment of Kinesin Heavy Chain produced in E. coli has a molecular mass of approximately 22 KDa.
>95% as determined by SDS-PAGE.
PDB rendering based on 2gry.
The kinesin family of motor proteins comprises at least two forms of conventional kinesin, and they are encoded by different genes and designated as ubiquitous kinesin, which is expressed in all cells and tissues, and neuronal kinesin, which is expressed exclusively in neuronal cells. While the kinesin heavy chain contains motor activity, evidence suggests that the kinesin light chain is involved in either modulation of kinesin heavy chain activity or in cargo binding. The motor protein kinesin is a heterotetramer composed of two heavy chains of approximately 120 kDa and two light chains of approximately 65 kDa. Kinesin motor activity is dependent on the presence of ATP and microtubules. rh-cKHC is a C-terminal fragment of uKHC with a histidine-tagged expressed in E. coli.
ATP binding, microtubule motor activity, nucleotide binding
HK2; KIF2; Kinesin-2; Kinesin, heavy chain, 2; Kinesin-like protein KIF2A; kinesin heavy chain member 2; kinesin heavy chain member 2A