Close

Recombinant Human Interleukin-1 alpha (CRP0878)

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Human Interleukin-1 alpha CRP0878 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Human Interleukin-1 alpha produced in E.coli is a single non-glycosylated polypeptide chain containing 159 amino acids and having a molecular mass of approximately 18 KDa.
  • Specificity
  • Fully biologically active when compared to standard. The ED50 as determined by the dose-dependant stimulation of murine D10S cells is less then 0.001 ng/ml, corresponding to a Specific Activity of 1 x 109 IU/mg.
  • Endotoxin
  • Less than 1EU/mg of rHuIL-1α as determined by LAL method.
  • Purity
  • >97% by SDS-PAGE and HPLC analyses.
  • Storage
  • This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
  • Reconstitution
  • We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.
  • Recombinant Human Interleukin-1 alpha
    Crystal structure of IL-1a (PDB2ILA).

BACKGROUND

  • Antigen Description
  • IL-1 alpha is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1alpha and IL-1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1beta is a secreted cytokine, IL-1alpha is predominantly a cell-associated cytokine.
  • Function
  • interleukin-1 receptor binding, protein binding, signal transducer activity.
  • Gene ID
  • 3552
  • Synonyms
  • IL-1A; IL1; IL1-ALPHA; IL1F1; IL1A (IL1F1); hematopoietin-1; preinterleukin 1 alpha; pro-interleukin-1-alpha; IL-1 alpha; IL-1α; IL1A (IL1F1); Interleukin-1 alpha precursor; interleukin 1 alpha

Related Products

Online Inquiry

Verification code
Click image to refresh the verification code.

CONTACT US

45-1 Ramsey Road, Shirley, NY 11967, USA
Call us at:
USA: 1-631-381-2994
Europe: 44-207-097-1828
Fax: 1-631-207-8356
Email:
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us