Recombinant Human Interleukin-13

DESCRIPTION	CATALOG #	SIZE	PRICE
Recombinant Human Interleukin-13	CRP0887	1mg	Please Inquiry

Product Detail

Product Overview: Recombinant Human Interleukin-13 produced in E.coli is a single non-glycosylated polypeptide chain containing 112 amino acids and having a molecular mass of approximately 12 kDa.

Specificity: Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent proliferation of TF-1 cells was < 1.0 ng/ml, corresponding to a specific activity of > 1×106 units/mg.

Storage: This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.

Background

Antigen Description: The human IL-13 cDNA encodes a 132 amino acid protein containing a proposed 20 amino acid signal peptide. Human IL-13 shares approximately 30% amino acid sequence homology to human IL-4 and the two cytokines exhibit overlapping biological activities. Human IL-13 is produced by activated Th0, Th1-like Th2-like and CD8 T cells. Similarly to IL-4, IL-13 has multiple effects on the differentiation and functions of monocytes/macrophages. IL-13 can suppress the cytotoxic functions of monocytes/macrophages. It can also suppress the production of proinflammatory cytokines and upregulate the production of IL-1ra by monocytes/macrophages.

Function: interleukin-13 receptor binding;protein binding;signal transducer activity

Synonyms: ALRH; BHR1; P600; IL-13; MGC116786; MGC116788; MGC116789; interleukin 13; IL13_HUMAN; Interleukin-13 [Precursor]; NC30.