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Recombinant Human Interleukin-13 (CRP0887)

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Human Interleukin-13 CRP0887 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Human Interleukin-13 produced in E.coli is a single non-glycosylated polypeptide chain containing 112 amino acids and having a molecular mass of approximately 12 kDa.
  • Specificity
  • Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent proliferation of TF-1 cells was < 1.0 ng/ml, corresponding to a specific activity of > 1×106 units/mg.
  • Endotoxin
  • Less than 1EU/mg of rHuIL-13 as determined by LAL method.
  • Purity
  • >95% by SDS-PAGE and HPLC analyses
  • Storage
  • This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
  • Reconstitution
  • We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.
  • Recombinant Human Interleukin-13
    PDB rendering based on 1ga3. Available structures:1ga3,1ijz,1ik0

BACKGROUND

  • Antigen Description
  • The human IL-13 cDNA encodes a 132 amino acid protein containing a proposed 20 amino acid signal peptide. Human IL-13 shares approximately 30% amino acid sequence homology to human IL-4 and the two cytokines exhibit overlapping biological activities. Human IL-13 is produced by activated Th0, Th1-like Th2-like and CD8 T cells. Similarly to IL-4, IL-13 has multiple effects on the differentiation and functions of monocytes/macrophages. IL-13 can suppress the cytotoxic functions of monocytes/macrophages. It can also suppress the production of proinflammatory cytokines and upregulate the production of IL-1ra by monocytes/macrophages.
  • Function
  • interleukin-13 receptor binding;protein binding;signal transducer activity
  • Gene ID
  • 3596
  • Synonyms
  • ALRH; BHR1; P600; IL-13; MGC116786; MGC116788; MGC116789; interleukin 13; IL13_HUMAN; Interleukin-13 [Precursor]; NC30.

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