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Recombinant Human Interleukin-16 (CRP0824)

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Human Interleukin-16 CRP0824 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Human IL-16 produced in E. coli is a single, non-glycosylated polypeptide chain containing 130 amino acids and having a molecular mass of 13.4 kDa.
  • Specificity
  • rHuIL-16 is fully biologically active when compared to standard. The ED50 as determined by its ability to chemoattract human CD4+ T lymphocytes using a concentration range of 10.0-100.0 ng/ml, corresponding to a Specific Activity greater than 1.0 x 104 IU/ mg.
  • Endotoxin
  • Less than 0.1ng/ug (1 IEU/ug) determined by LAL test.
  • Purity
  • >97% as determined by RP-HPLC, FPLC and SDS-PAGE.
  • Storage
  • Lyophilized rHuIL-16 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution rHuIL-16 should be stored at 4°C between 2-7 days and for future use below -18°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Aliquot to avoid repeated freeze-thaw cycles.
  • Reconstitution
  • It is recommended to reconstitute the lyophilized rHuIL-16 in sterile 18MΩ-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.
  • Recombinant Human Interleukin-16
    PDB rendering based on 1i16.

BACKGROUND

  • Antigen Description
  • IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, human IL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4+ T cells. Human and murine IL-16 show significant cross-species reactivity.
  • Function
  • cytokine activity; protein binding
  • Gene ID
  • 3603
  • Synonyms
  • FLJ16806, FLJ42735, FLJ44234, LCF, prIL-16, IL16, Interleukin-16, Lymphocyte Chemoattractant Factor, prIL-16, IL-16, HsT19289 ; interleukin-16 precursor; interleukin 16 (lymphocyte chemoattractant factor)

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