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Recombinant Human Interleukin-17 (CRP0837)

Datasheet
DESCRIPTION CATALOG # SIZE PRICE
Recombinant Human Interleukin-17 CRP0837 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant human IL-17 produced in E.coli is a 31.0kDa disulfide-linked homodimer of two 136 amino acid polypeptide chains.
  • Specificity
  • The ED50 as determined by the dose-dependent induction of IL-6 in Hs68 cell line was found to be approximately 2ng/ml, corresponding to a specific activity of 5.0 x 105 IU/mg.
  • Endotoxin
  • Less than 1 IEU/ug determined by LAL test.
  • Purity
  • >95% as determined by SDS-PAGE.
  • Storage
  • Lyophilized rHuIL-17 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution rHuIL-17 should be stored at 4°C between 2-7 days and for future use below -18°C. Aliquot to avoid repeated freeze-thaw cycles.
  • Reconstitution
  • It is recommended to reconstitute the lyophilized rHuIL-17 in sterile 18MΩ-H2O containing at least 0.1% human serum albumin or bovine serum albumin to prepare a stock solution of no less than 100ug/ml of the cytokine.

BACKGROUND

  • Antigen Description
  • The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 132 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells.
  • Function
  • Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts.
  • Gene ID
  • 3605
  • Synonyms
  • IL17,CTLA-8, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8, Interleukin-17A, CTLA8 ; Interleukin-17A Precursor

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