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Recombinant Human IL-6 produced in E. coli is a single, non-glycosylated polypeptide chain containing 185 amino acids and having a molecular mass of 21.0 kDa.
rHuIL-6 is fully biologically active when compared to standard. The ED50 as determined by the dose-dependant stimulation of human TF-1 cells is less than 0.1 ng/ml, corresponding to a Specific Activity of 5.0 x 107 IU/mg.
Less than 0.3ng/ug (0.3IEU/ug) determined by LAL test.
>98% by SDS-PAGE, FPLC and RP-HPLC.
Lyophilized rHuIL-6 although stable at room temperature for 3 weeks, should be stored desiccated below -18oC. Upon reconstitution rHuIL-6 should be stored at 4oC between 2-7 days and for future use below -18oC. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Aliquot to avoid repeated freeze-thaw cycles.
It is recommended to reconstitute the lyophilized rHuIL-6 in sterile 18MΩ-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.
PDB rendering based on 1ALU.
Interleukin (IL)-6 is an important proinflammatory and immunoregulatory cytokine expressed by various cells. Interleukin-6 has been shown to inhibit the growth of early stage and to promote the proliferation of advanced stage melanoma cells in vitro.
Cytokine activity, Interleukin-6 receptor binding, Protein binding