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Recombinant Human Interleukin-8 (8-79) (CRP0825)

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Human Interleukin-8 (8-79) CRP0825 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Human IL-8 (8-79) produced in E. coli is a single, non-glycosylated polypeptide chain containing 72 amino acids and having a molecular mass of 8452 Dalton.
  • Specificity
  • rHuIL-8 /72 is fully biologically active when compared to standard. The ED50 as determined by its chemotaxis of hCXCR-2 transfected mouse BaF/3 cells is less than 2 ng/ml, corresponding to a Specific Activity of 5.0 x 105IU/ mg.
  • Endotoxin
  • Less than 0.1ng/ug (1 IEU/ug) determined by LAL test.
  • Purity
  • >95% as determined by RP-HPLC and SDS-PAGE.
  • Storage
  • Lyophilized rHuIL-8 /72 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution rHuIL-8 /72 should be stored at 4°C between 2-7 days and for future use below -18°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Aliquot to avoid repeated freeze-thaw cycles.
  • Reconstitution
  • It is recommended to reconstitute the lyophilized rHuIL-8 /72 in sterile 18MΩ-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.
  • Recombinant Human Interleukin-8 (8-79)
    PDB rendering based on 1IL8.

BACKGROUND

  • Antigen Description
  • Interleukin-8 (IL-8) belongs to the neutrophil-specific CXC family of chemokines. It is one of the initial cytokines released from a variety of cell types, including T cells, endothelial cells and fibroblasts, in response to an inflammatory stimulus and acts by recruiting neutrophils, T-cells and basophils to the site of inflammation. Elevated Interleukin-8 levels are associated with the onset of a variety of disease states.
  • Function
  • chemokine activity; interleukin-8 receptor binding; protein binding
  • Gene ID
  • 3576
  • Synonyms
  • 3-10C, AMCF-I, CXCL8, GCP-1, Monocyte-derived neutrophil chemotactic factor, MDNCF, T-cell chemotactic factor, Neutrophil-activating protein 1, NAP-1, Protein 3-10C, Granulocyte chemotactic protein 1, Monocyte-derived neutrophil-activating peptide, MONAP, Emoctakin, K60, NAF, LECT, LUCT, LYNAP, SCYB8, TSG-1, b-ENAP;GCP1; IL-8; NAP1; C-X-C motif chemokine 8;Interleukin-8 precursor ;beta-thromboglobulin-like protein; chemokine (C-X-C motif) ligand 8;lymphocyte-derived neutrophil-activating factor ;small inducible cytokine subfamily B member 8

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